Narva, K., U. Toprak, A. Alyokhin, R. Groves, J.L. Jurat‐Fuentes, W. Moar, R. Nauen, S. Whipple, and G. Head. 2025. Insecticide resistance management scenarios differ for RNA‐based sprays and traits. Insect Molecular Biology 34: 518-526.

Insecticides, Microevolution /

RNA-based bioinsecticides that comprise a dsRNA active ingredient and function by RNA interference (RNAi) are being commercialised as insecticidal traits in transgeniccrops and as sprayable biopesticides. These RNAi insecticidal technologies are valuable alternatives to conventional chemical insecticides due to their efficacy, high degree ofspecificity and favourable human and environmental safety profiles. As with all pesticides, […]

Narva, K., U. Toprak, A. Alyokhin, R. Groves, J.L. Jurat‐Fuentes, W. Moar, R. Nauen, S. Whipple, and G. Head. 2025. Insecticide resistance management scenarios differ for RNA‐based sprays and traits. Insect Molecular Biology 34: 518-526. Read More »

Alyokhin, A.V., B.M. Rosenthal, D.C. Weber, and M.B. Baker. 2025. Towards a unified approach in managing resistance to vaccines, drugs, and pesticides. Biological Reviews 100: 1067-1082.

Insecticides, Microevolution, Reviews

Everywhere, pests and pathogens evolve resistance to our control efforts, impairing human health and welfare. Developing sustainable solutions to this problem requires working with evolved immune and ecological systems, rather than against these evolutionary forces. We advocate a transdisciplinary approach to resistance based on an evolutionary foundation informed by the concepts of integrated pest management

Alyokhin, A.V., B.M. Rosenthal, D.C. Weber, and M.B. Baker. 2025. Towards a unified approach in managing resistance to vaccines, drugs, and pesticides. Biological Reviews 100: 1067-1082. Read More »

Wenninger, E.J., S.P. DeGrey, J. Insinga, E. Knopf, A. Alyokhin, E. R. Barnes, B. Bradford, R. L. Groves, B. Manley, and J. Piaskowski, 2025. Responses of non-target arthropods to the dsRNA bioinsecticide Calantha™ and conventional insecticides targeting Colorado potato beetle, Leptinotarsa decemlineata (Say). American Journal of Potato Research 102: 129-151.

Abundance Factors, Insecticides /

Management of the Colorado potato beetle (Leptinotarsa decemlineata) is reliant on conventional insecticides that can negatively affect non-target arthropods. Calantha™ (active ingredient: ledprona) is a sprayable double-stranded RNA biopesticide specific for L decemlineata proteasome subunit beta 5 gene that triggers the RNA-interference pathway and is designed to have limited non-target effects. To test this hypothesis,

Wenninger, E.J., S.P. DeGrey, J. Insinga, E. Knopf, A. Alyokhin, E. R. Barnes, B. Bradford, R. L. Groves, B. Manley, and J. Piaskowski, 2025. Responses of non-target arthropods to the dsRNA bioinsecticide Calantha™ and conventional insecticides targeting Colorado potato beetle, Leptinotarsa decemlineata (Say). American Journal of Potato Research 102: 129-151. Read More »

Gao, Y., A. Alyokhin, A., S.M. Prager, S. Reitz, and A. Huseth. 2025. Complexities in the implementation and maintenance of integrated pest management in potato. Annual Review of Entomology 70: 45-63.

Reviews / , ,

Integrated pest management (IPM) is an educated and systematic effort to use multiple control techniques to reduce pest damage to economically acceptable levels while minimizing negative environmental impacts. Although its benefits are widely acknowledged, IPM is not universally practiced by farmers. Potato farming, which produces one of the most important staple crops in the world,

Gao, Y., A. Alyokhin, A., S.M. Prager, S. Reitz, and A. Huseth. 2025. Complexities in the implementation and maintenance of integrated pest management in potato. Annual Review of Entomology 70: 45-63. Read More »

Gao, Y., A. Alyokhin, R. Zhang, G. Smagghe, S.R. Palli, J.L. Jurat-Fuentes, and B.E. Tabashnik. 2024. Proactive resistance management for sustaining the efficacy of RNA interference for pest control. Journal of Economic Entomology 117: 1306-1308.

Insecticides, Microevolution /

Biopesticides based on RNA interference (RNAi) took a major step forward with the first registration of a sprayable RNAi product, which targets the world’s most damaging potato pest. Proactive resistance management is needed to delay the evolution of resistance by pests and sustain the efficacy of RNAi biopesticides.

Gao, Y., A. Alyokhin, R. Zhang, G. Smagghe, S.R. Palli, J.L. Jurat-Fuentes, and B.E. Tabashnik. 2024. Proactive resistance management for sustaining the efficacy of RNA interference for pest control. Journal of Economic Entomology 117: 1306-1308. Read More »

Yan, J., R. Nauen, S. Reitz, A. Alyokhin, J. Zhang, D. Mota-Sanchez, Y. Kim, S. R. Palli, S. I. Rondon, B. A. Nault, and J. L. Jurat-Fuentes, M. S. Crossley, W. E. Snyder, A.M.R. Gatehouse, M. P. Zalucki, B. E. Tabashnik, and Y. Gao. 2024. The new kid on the block in insect pest management: sprayable RNAi goes commercial. SCIENCE CHINA Life Sciences 67: 1766-1768.

Insecticides /

No abstract available, please email me for a reprint.

Yan, J., R. Nauen, S. Reitz, A. Alyokhin, J. Zhang, D. Mota-Sanchez, Y. Kim, S. R. Palli, S. I. Rondon, B. A. Nault, and J. L. Jurat-Fuentes, M. S. Crossley, W. E. Snyder, A.M.R. Gatehouse, M. P. Zalucki, B. E. Tabashnik, and Y. Gao. 2024. The new kid on the block in insect pest management: sprayable RNAi goes commercial. SCIENCE CHINA Life Sciences 67: 1766-1768. Read More »

Moyet, M., A. Alyokhin, A. Buzza, and L.B. Perkins. 2023. Black soldier fly larvae as a recycling agent for cull potatoes. American Journal of Potato Research 100: 441-450.

Insect Husbandry /

The accumulation of cull potato piles is a concern because they take up space and harbor potato-associated pathogens. Black soldier fly, Hermetia illucens, larvae are an increasingly popular agent for converting organic wastes into ingredients for animal feeds. In this investigation, their ability to process cull potato waste was assessed. Potato tubers were suitable for

Moyet, M., A. Alyokhin, A. Buzza, and L.B. Perkins. 2023. Black soldier fly larvae as a recycling agent for cull potatoes. American Journal of Potato Research 100: 441-450. Read More »

Pallis, S., A. Alyokhin, B. Manley, T. Rodrigues, E. Barnes, and K. Narva. 2023. Baseline susceptibility to a novel dsRNA-based insecticide across US populations of Colorado potato beetle. Agriculture 2023, 13, 2283. https://doi.org/10.3390/agriculture13122283

Insecticides /

The Colorado potato beetle, Leptinotarsa decemlineata (Say) (Coleoptera: Chrysomelidae) is an insect defoliator of the potato, Solanum tuberosum L. This species thrives in agricultural environments because of its flexible and complex life history, as well as its ability to evolve insecticide resistance. As a result, it has become a widely distributed agricultural pest. Ledprona (trade

Pallis, S., A. Alyokhin, B. Manley, T. Rodrigues, E. Barnes, and K. Narva. 2023. Baseline susceptibility to a novel dsRNA-based insecticide across US populations of Colorado potato beetle. Agriculture 2023, 13, 2283. https://doi.org/10.3390/agriculture13122283 Read More »

Pallis, S., A. Alyokhin, B. Manley, T. Rodrigues, E. Barnes, and K. Narva. 2023. Effects of low doses of a novel dsRNA-based biopesticide (Calantha) on the Colorado potato beetle. Journal of Economic Entomology 116: 456-461

Insecticides /

The Colorado potato beetle, Leptinotarsa decemlineata (Coleoptera: Chrysomelidae) is a destructive pest of the cultivated potato, Solanum tuberosum. Members of this species are well-suited to agricultural habitats because of a suite of physiological adaptations and their ability to evolve resistance to multiple insecticides. Recently, a novel double-stranded RNA (dsRNA) insecticide (Calantha, active ingredient ledprona) has

Pallis, S., A. Alyokhin, B. Manley, T. Rodrigues, E. Barnes, and K. Narva. 2023. Effects of low doses of a novel dsRNA-based biopesticide (Calantha) on the Colorado potato beetle. Journal of Economic Entomology 116: 456-461 Read More »

Moyet, M., H. Morrill, D. Leal Espinal, E. Bernard, and A. Alyokhin. 2023. Early growth patterns of Bacillus cereus on potato substrate in the presence of low densities of black soldier fly larvae. Microorganisms 11(5): 1284. https://doi.org/10.3390/microorganisms11051284

Insect Husbandry /

Bacillus cereus is a common and ubiquitous bacterium that can cause foodborne illnesses in humans and other animals. Common methods of contact between foodborne pathogens and their victims include exposure through contaminated food or food containment products. Using larvae of black soldier flies, Hermetia illucens, for biological conversion of wastes into components of animal feeds

Moyet, M., H. Morrill, D. Leal Espinal, E. Bernard, and A. Alyokhin. 2023. Early growth patterns of Bacillus cereus on potato substrate in the presence of low densities of black soldier fly larvae. Microorganisms 11(5): 1284. https://doi.org/10.3390/microorganisms11051284 Read More »